Phospho-RUNX1 (Ser435) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Acute myeloid leukemia 1 protein, CBFA2, CBFA2, alpha 2 subunit, RUNX1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q01196 | | Иммуноген | Peptide sequence around phosphorylation site of Serine 435( S-N-S(p)-P-T) derived from Human AML1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.<br/><br/>Miyoshi H., Proc. Natl. Acad. Sci. U.S.A. 88:10431-10434(1991).<br />Sacchi N., Genes Chromosomes Cancer 11:226-236(1994).<br />Nucifora G., Blood 81:2728-2734(1993).<br /></p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser435 | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Developmental biology,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA110286 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-RUNX1 (Ser435) Antibody.
Примечание: дополнительная информация (на английском языке). |
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