| Объем | 50 мкл |
| Синонимы | Mixed lineage kinase domain-like protein, hMLKL, MLKL |
| Тип антител | Recombinant Antibody |
| Species | Human |
| UniProt ID | Q8NB16 |
| Иммуноген | A synthesized peptide derived from human Phospho-MLKL (S358) |
| Видовая специфичность | Human |
| Применение | ELISA, IHC, Recommended dilution: IHC:1:50-1:200 |
| Клональность | Monoclonal |
| Изотип | Rabbit IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Affinity-chromatography |
| Области исследований | Signal Transduction |
| Аббревиатура | Mixed lineage kinase domain-like protein |
| Примечание | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. |
| Ссылка на страницу на сайте производителя | ссылка |
IHC image of CSB-RA850851A358phHU diluted at 1:100 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Наименование: Phospho-MLKL (S358) Antibody.