KRT17 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Keratin, type I cytoskeletal 17, Cytokeratin-17, CK-17, K17 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q04695 | | Иммуноген | Synthesized peptide derived from human keratin 17. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 | | Примечание | May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair By similarity.<br/><br/>M Rosenberg, Mol. Cell. Biol., Feb 1988, 8: 722 - 736.<br/>SM Troyanovsky, J. Cell Sci., Jul 1989, 93: 419.<br/>Kevin M. McGowan, Genes & Dev., Jun 2002, 16: 1412.<br/>Nicholas Bianchi, Mol. Cell. Biol., Aug 2005, 25: 7249 - 7259." | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HuvEc cells, using keratin 17 antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using keratin 17 antibody.
 | Immunofluorescence analysis of HepG2 cells, using keratin 17 antibody.
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Наименование: KRT17 Antibody.