| Объем | 100 мкл |
| Синонимы | 59 kDa serine/threonine protein kinase, EC 2.7.11.1, ILK-1, ILK1, Integrin-linked protein kinase |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q13418 |
| Иммуноген | Synthesized non-phosphopeptide derived from human ILK around the phosphorylation site of serine 246 (I-F-S(p)-H-P). |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.<br/><br/>Hannigan G.E.,Nature 379:91-96(1996).<br/>Janji B.,Oncogene 19:3069-3077(2000).<br/>Tadic B.,Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from rat liver cells, using ILK (Ab-246) antibody.
 |
Immunohistochemistry analysis of paraffin-embedded human brain tissue using ILK (Ab-246) antibody.
 |
| | |
Наименование: ILK (Ab-246) Antibody.