GRIN1 (Ab-897) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | GLURZ1, GRIN1, NMD-R1, NMDZ1, NMZ1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q05586 | | Иммуноген | Peptide sequence around aa.895~899 (R-S-S-K-D) derived from Human NMDAR1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, IF,IF:1:100-1:200 | | Примечание | NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.<br/><br/>Tyszkiewicz JP, et al. J Physiol. 2004 Feb 1, 554(Pt 3): 765-777 | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Neuroscience | | Ссылка на страницу на сайте производителя | ссылка | Immunofluorescence staining of methanol-fixed Hela cells using NMDAR1(Ab-897) Antibody.
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Наименование: GRIN1 (Ab-897) Antibody.