TP53INP1 AntibodyСпецификация| Объем | 50 мкл | | Синонимы | tumor protein p53 inducible nuclear protein 1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q96A56 | | Иммуноген | Synthetic peptide of human TP53INP1 | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC,ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 | | Примечание | TP53INP1 (tumor protein p53-inducible nuclear protein 1), also known as p53DINP1, SIP or Teap, is a 240 amino acid protein that localizes to nuclear bodies and exists as two alternatively spliced isoforms, designated p53DINP1a and p53DINP1b. Expressed ubiquitously with higher expression in testis, pancreas and spleen tissue, TP53INP1 functions in response to double-stranded DNA breaks and regulates p53-mediated apoptosis, specifically by phosphorylating human p53 at Ser 46, an event that leads to cell death. Additionally, TP53INP1 is thought to interact with p73 and may be involved in the regulation of p73-controlled cell cycle progression. TP53INP1 expression is downregulated in pancreatic ductal adenocarcinomas, suggesting that, via its ability to induce cell death, TP53INP1 plays a role in tumor suppression. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen affinity purification | | Области исследований | Cancer,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA052632(TP53INP1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ?200)
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA052632(TP53INP1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ?200)
 | Gel: 10%SDS-PAGE, Lysate: 40 ?g, Lane 1-3: Human fetal liver tissue, 293T cells, 231 cells, Primary antibody: CSB-PA052632(TP53INP1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Наименование: TP53INP1 Antibody.