| Объем | 100 мкл |
| Синонимы | kinase TLK1, PKU-beta, tousled-like kinase 1, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9UKI8 |
| Иммуноген | Synthesized peptide derived from internal of human TLK1. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.<br/><br/>Yamakawa A., Gene 202:193-201(1997).<br/>Sillje H.H.W., EMBO J. 18:5691-5702(1999).<br/>Cabaniols J.-P., Mol. Biol. Cell 10:4033-4041(1999).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from rat brain cells and NIH/3T3 cells, using TLK1 antibody.
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Наименование: TLK1 Antibody.