SNAI1 (Ab-246) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | SNAH, SNAI, Sna, Snail, zinc finger protein SNAI1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O95863 | | Иммуноген | Synthesized non-phosphopeptide derived from human SNAI1 around the phosphorylation site of serine 246 (T-F-S(p)-R-M). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.<br/><br/>Okubo T., Cancer Res. 61:1338-1346(2001).<br/>Twigg S.R., Hum. Genet. 105:320-326(1999).<br/>Paznekas W.A., Genomics 62:42-49(1999)<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cardiovascular | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HT29 cells, using SNAI1 (Ab-246) antibody.
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Наименование: SNAI1 (Ab-246) Antibody.