SIRPA AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Bit, MFR, MYD-1 antigen, MYD1, Macrophage fusion receptor | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P78324 | | Иммуноген | Synthesized peptide derived from human SIRP-alpha1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.<br/><br/>Kentaro Ide, PNAS, Mar 2007, 104: 5062 - 5066. <br/>Thomas T. Chen, Cancer Res., Jan 2004, 64: 117 - 127. <br/>Shu Q. Liu, J. Biol. Chem., Nov 2005, 280: 39294 - 39301. <br/>Gurpreet S. Kapoor, Cancer Res., Sep 2004, 64: 6444 - 6452. <br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Neuroscience,Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human brain tissue using Sirp ?1 antibody.
 | Western blot analysis of extracts from HepG2 cells, using Sirp ?1 antibody.
 | Western blot analysis of extracts from colo cells (Lane 2), using Sirp ?1 antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: SIRPA Antibody.