Phospho-MDM2 (Ser186/Ser188) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Oncoprotein Mdm2, p53-binding protein Mdm2, Ubiquitin-protein ligase E3 Mdm2, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q00987 | | Иммуноген | Peptide sequence around phosphorylation site of Ser186/Ser188(H-K-S(p)-D-S(p)-I-S) derived from Human MDM2. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, IF,IF:1:100-1:200 | | Примечание | <p>This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues<br/><br/>M Zhou, Blood, Mar 1995, 85: 1608 - 1614. <br />Susan M. Mendrysa, Mol. Cell. Biol., Mar 2000, 20: 2023 - 2030. <br />M. Saeed Sheikh, Cancer Res., Jul 1993, 53: 3226 - 3228.<br /></p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser186/Ser188 | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Immunofluorescence staining of methanol-fixed HeLa cells using MDM2 (Phospho-Ser186/Ser188) Antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA570037 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-MDM2 (Ser186/Ser188) Antibody.
Примечание: дополнительная информация (на английском языке). |
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