| Объем | 100 мкл |
| Синонимы | WARTS, Large tumor suppressor 1, EC 2.7.11.1, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | O95835/Q9NRM7 |
| Иммуноген | Peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T(p)-F-R) derived from Human LATS1/2 . |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, IHC,IHC:1:50-1:100 |
| Примечание | <p>The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. <br/><br/>Tao W., Nat. Genet. 21:177-181(1999).<br />Nishiyama Y., FEBS Lett. 459:159-165(1999).<br />The MGC Project Team, Genome Res. 14:2121-2127(2004).</p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Thr1079/1041 |
| Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemical analysis of paraffin-embedded human brain tissue using LATS1/2 (Phospho-Thr1079/1041) antibody (left)or the same antibody preincubated with blocking peptide (right).
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Наименование: Phospho-LATS1/LATS2 (Thr1079/1041) Antibody.