Phospho-INSR (Tyr1355) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CD220 antigen, IR, insulin receptor, kinase InsR, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P06213 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 1355 (R-S-Y(p)-E-E) derived from Human IR. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. <br/><br/>Tennagels N, et al. (2001) Biochem Biophys Res Commun 282, 387-93 <br />Tennagels N, Bergschneider E, Al-Hasani H, Klein HW (2000) FEBS Lett 479, 67-71 <br />Noelle V, Tennagels N, Klein HW (2000) Biochemistry 39, 7170-7 </p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr1355 | | Области исследований | Neuroscience,Cancer,Cardiovascular,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 cells treated with Heatshock using Phospho-IR (Tyr1355) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA203919 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-INSR (Tyr1355) Antibody.
Примечание: дополнительная информация (на английском языке). |
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