NFKBIA (Ab-32/36) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | I-kappa-B-alpha, IkappaBalpha, IKBA, MAD3, Major histocompatibility complex enhancer-binding protein MAD3 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P25963 | | Иммуноген | Synthesized non-phosphopeptide derived from human IκB-alpha around the phosphorylation site of Serine 32/36. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.<br/><br/>Mattioli I, et al. (2004)J Immunol, 172(10): 6336-44.<br/>Courtois G, et al. (2003)J Clin Invest, 112(7): 1108-15.<br/>Nair A, et al. (2003) Oncogene, 22(1): 50-8.<br/>Fan C, et al. (2002)J Cell Sci, 115(Pt 24): 4843-53.<br/>Schubert SY, et al. (2002)FASEB J, 16(14): 193 | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Immunology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from MCF7 cells, treated with TNF-?, using IkappaB-alpha (Ab-32/36) antibody.
 | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using IkappaB-alpha (Ab-32/36) antibody.
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Наименование: NFKBIA (Ab-32/36) Antibody.