MMP13 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CLG3, Collagenase 3, MANDP1, matrix metallopeptidase 13, MMP13 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P45452 | | Иммуноген | Peptide sequence around aa.355~359 (F-W-A-L-N) derived Human from MMP-13. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <div> ,Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.</div><div> ,</div><div>Guo A, et al. Proc Natl Acad Sci U S A 105, 692-7(2008)</div><div>Rikova K, et al. Cell 131, 1190-203 (2007)</div><div> ,</div> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Cancer,Cardiovascular,Cell biology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from MCF,MDA231,MDA435 and HT29 cells using MMP-13 Antibody .
 | | | |
Информация для заказа |
Наименование: MMP13 Antibody.