MCM2 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | BM28, CDCL1, DNA replication licensing factor MCM2, KIAA0030, MCMD2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P49736 | | Иммуноген | Synthesized peptide derived from human MCM2. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.<br/><br/>H Yan, Genes & Dev., Jun 1991, 5: 944 - 957. <br/>Yukio Ishimi, J. Biol. Chem., Nov 2001, 276: 42744 - 42752.<br/>Muluye E. Liku, Mol. Biol. Cell, Oct 2005, 16: 5026 - 5039.<br/>Daniela S. Dimitrova, J. Cell Biol., Aug 1999, 146: 709. <br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MCM2 antibody.
 | Western blot analysis of extracts from 293 cells, using MCM2 antibody.
 | Western blot analysis of extracts from 3T3 cells (Lane 2), k562 cells (Lane 3) and HepG2 cells (Lane 4), using MCM2 antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: MCM2 Antibody.