MADD AntibodyСпецификация| Объем | 100 мкл | | Синонимы | MAP kinase-activating death domain protein, Differentially expressed in normal and neoplastic cells, Insulinoma glucagonoma clone 20, Rab3 GDP/GTP exchange factor, MADD | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q8WXG6 | | Иммуноген | Synthesized peptide derived from internal of human MADD. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 | | Примечание | Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis), isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.<br/><br/>Chow V.T.K., DNA Seq. 6:263-273(1996).<br/>Schievella A.R., J. Biol. Chem. 272:12069-12075(1997).<br/>Chow V.T.K., Genome 41:543-552(1998).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cancer,Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from COLO cells, HeLa cells and Jurkat cells, using MADD antibody.
 | Immunohistochemistry analysis of paraffin-embedded human brain tissue using MADD antibody.
 | Immunofluorescence analysis of A549 cells, using MADD antibody.
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Наименование: MADD Antibody.