ООО «Лабораторная Диагностика»
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/ Каталог / Реагенты для научных исследований / Антитела / Поликлональные антитела Cusabio

CRYAB Antibody

Спецификация

Объем50 мкл
Синонимыcrystallin, alpha B
КлональностьPolyclonal Antibody
ОрганизмHuman
uniprotP02511
ИммуногенFusion protein of human CRYAB
ИсточникRabbit
Видовая специфичностьHuman, Mouse, Rat
ПрименениеELISA, WB, IHC,ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200
ПримечаниеCrystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy.
Клональность1Polyclonal
ИзотипIgG
КоньюгатNon-conjugated
Буффер-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
ФормаLiquid
ХранениеUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очисткиAntigen affinity purification
Области исследованийNeuroscience,Cancer,Metabolism,Signal transduction
Ссылка на страницу на сайте производителяссылка
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA178887(CRYAB Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ?200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA178887(CRYAB Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ?200)
Gel: 12%SDS-PAGE, Lysate: 40 ?g, Lane 1-3: Mouse heart tissue, human chromaffin cell tumor tissue, mouse muscle tissue, Primary antibody: CSB-PA178887(CRYAB Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  

Информация для заказа

Область использования:Производство:Cusabio
Метод:Антитела 
Объем:50 мкл 
Кат. номер:CSB-PA178887
Цена (с НДС 20%):по запросуВ корзину
CRYAB AntibodyНаименование: CRYAB Antibody.
Примечание: дополнительная информация (на английском языке).
   
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info@LD.ru   тел.: +7 495 369-20-43