DNM1L (Ab-637) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | DLP1, DNM1L, Dnm1p/Vps1p-like protein, DRP1, DVLP | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O00429 | | Иммуноген | Synthesized peptide derived from C-terminal of human DNM1L. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L)which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.<br/><br/>Shin H.-W., J. Biochem. 122:525-530(1997).<br/>Hong Y.-R., Biochem. Biophys. Res. Commun. 249:697-703(1998).<br/>Imoto M., J. Cell Sci. 111:1341-1349(1998).<br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Neuroscience,Cancer,Cell biology,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HuvEc cells (Lane 2), HepG2 cells (Lane 3), colo cells (Lane 4), 293 cells (Lane 5) and JK cells (Lane 6), using DRP1 (Ab-637) antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: DNM1L (Ab-637) Antibody.