DKC1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CBF5 homolog, DKC1, EC 5.4.99.-, Nucleolar protein NAP57, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O60832 | | Иммуноген | Synthesized peptide derived from Internal of human Dyskerin. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 | | Примечание | Isoform 1:Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.Isoform 3:Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells).<br/><br/>Heiss N.S., Nat. Genet. 19:32-38(1998).<br/>Knight S.W., Am. J. Hum. Genet. 65:50-58(1999).<br/>Hassock S., Genomics 55:21-27(1999).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HeLa cells, using Dyskerin antibody.
 | Immunofluorescence analysis of HeLa cells, using Dyskerin antibody.
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Наименование: DKC1 Antibody.