XRCC3 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | X-RAY REPAIR CROSS- COMPLEMENTING PROTEIN 3, X-RAY REPAIR, COMPLEMENTING DEFECTIVE IN CHINESE HAMSTER 3, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O43542 | | Иммуноген | Synthesized peptide derived from Internal of human XRCC3. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment, the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process, the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.<br/><br/>Hitoshi Kurumizaka, Nucleic Acids Res., Jul 2003, 31: 4041 - 4050. <br/>Anna Renglin Lindh, Hum. Mol. Genet., Apr 2006, 15: 1217 - 1224. <br/>Zhi-Yuan Xu, J. Pharmacol. Exp. Ther., Aug 2005, 314: 495 - 505. <br/>Nazumi Alice Yamada, J. Biol. Chem., May 2004, 279: 232 | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HepG2 cells, treated with Adriamycin (0.5uM, 5hours), using XRCC3 antibody.
 | Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using XRCC3 antibody.
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Наименование: XRCC3 Antibody.