| Объем | 100 мкл |
| Синонимы | tRNA-splicing endonuclease subunit Sen54, tRNA-intron endonuclease Sen54, HsSen54, TSEN54, SEN54 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q7Z6J9 |
| Иммуноген | Synthesized peptide derived from internal of human TSEN54. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.<br/><br/>Zody M.C., Nature 440:1045-1049(2006).<br/>Paushkin S.V., Cell 117:311-321(2004).<br/>Ota T., Nat. Genet. 36:40-45(2004).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 3T3 cells and Jurkat cells, using TSEN54 antibody.
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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TSEN54 antibody.
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Наименование: TSEN54 Antibody.