| Объем | 100 мкл |
| Синонимы | TIF1, TIF1A, TRIM24, Transcription intermediary factor 1-alpha, Tripartite motif protein 24 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | O15164 |
| Иммуноген | Synthesized peptide derived from C-terminal of human TRIM24. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes By similarity.<br/><br/>Thenot S., J. Biol. Chem. 272:12062-12068(1997).<br/>Venturini L., Oncogene 18:1209-1217(1999).<br/>Hellal-Levy C., Mol. Endocrinol. 14:1210-1221(2000).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from COLO cells, using TRIM24 antibody.
 |
Immunohistochemistry analysis of paraffin-embedded human brain tissue using TRIM24 antibody.
 |
| | |
Наименование: TRIM24 Antibody.