| Объем | 100 мкл |
| Синонимы | BMP-10, BMP10, Bone morphogenetic protein 10, MGC126783, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | O95393 |
| Иммуноген | Synthesized peptide derived from Internal of human BMP10. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.<br/><br/>Celeste A.J., Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.<br/>Hillier L.W., Nature 434:724-731(2005).<br/>Mazerbourg S., J. Biol. Chem. 280:32122-32132(2005).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Cardiovascular,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from Jurkat cells, using BMP10 antibody.
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Наименование: BMP10 Antibody.