TIMP1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | tissue inhibitor of metalloproteinase 1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P01033 | | Иммуноген | Synthesized peptide derived from internal of human TIMP1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro, but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.<br/><br/>Anieta M. Sieuwerts, Clin. Chem., May 2007, 10.1373.<br/>KM Fong, Clin. Cancer Res., Aug 1996, 2: 1369. <br/>E. Susol, Rheumatology, Dec 2000, 39: 1332 - 1336. <br/>Christopher J Jackson, Ann Rheum Dis, Mar 1998, 57: 158 - 161.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cancer,Cardiovascular,Cell biology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 cells, using TIMP1 antibody.
 | Western blot analysis of extracts from cos-7 cells (Lane 2), using TIMP1 antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: TIMP1 Antibody.