SYNCRIP AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Heterogeneous nuclear ribonucleoprotein Q, hnRNP Q, hnRNP-Q, Synaptotagmin-binding, cytoplasmic RNA-interacting protein | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O60506 | | Иммуноген | Synthesized peptide derived from Internal of human hnRNP Q. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 | | Примечание | Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation, seems not to be essential for GAIT complex function.<br/><br/>Harris C.E., J. Virol. 73:72-80(1999).<br/>Du G., Chin. Sci. Bull. 45:343-349(2000).<br/>Mourelatos Z., EMBO J. 20:5443-5452(2001).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Microbiology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HUVEC cells, Jurkat cells and 293 cells, using hnRNP Q antibody.
 | Immunofluorescence analysis of HepG2 cells, using hnRNP Q antibody.
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Наименование: SYNCRIP Antibody.