TP53 Monoclonal AntibodyСпецификация| Объем | 100 мкл | | Синонимы | P53, LFS1, TRP53, TP53 | | Видовая специфичность | Human | | Uniport ID | P04637 | | Иммуноген | Purified recombinant human p53 protein fragments expressed in E.coli. | | Источник | Mouse | | Видовая специфичность 1 | Human | | Применение | ELISA,WB,Recommended dilution:WB:1:500-1:5000 | | Примечание | Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. | | Изотип | IgG2b | | Метод очистки | Affinity purified | | Коньюгат | Non-conjugated | | Буффер | Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology | | Станица на сайте производителя | ссылка | | | |
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Наименование: TP53 Monoclonal Antibody.