SMAD2 (Ab-465) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | JV18-1, Mad-related protein 2, MADH2, MADR2, Mothers against decapentaplegic homolog 2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q15796 | | Иммуноген | Synthesized peptide derived from C-terminal of human Smad2. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.<br/><br/>Riggins G.J., Nat. Genet. 13:347-349(1996). <br/>Zhang Y., Nature 383:168-172(1996). <br/>Eppert K., Cell 86:543-552(1996).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Signal transduction,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 cells, JurKat cells, HepG2 cells and K562 cells, using Smad2 (Ab-465) antibody.
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Наименование: SMAD2 (Ab-465) Antibody.