UBR5 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CAK, CD167a antigen, Cell adhesion kinase, Discoidin receptor tyrosine kinase, EC 2.7.1.112 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O95071 | | Иммуноген | Synthesized peptide derived from Internal of human EDD. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation By similarity. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.<br/><br/>Michelle J. Henderson, J. Biol. Chem., Dec 2006, 281: 39990 - 40000. <br/>Lisa N. Kinch, Protein Sci., Feb 2005, 14: 360 - 367. <br/>Michelle J. Henderson, J. Biol. Chem., Jul 2002, 277: 26468 - 26478. <br/>Darren N. Saunders, Mol. Cell. Biol., Aug 2004, 24: 7225 - 7 | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using EDD antibody.
 | Western blot analysis of extracts from A549 cells, using EDD antibody.
 | Western blot analysis of extracts from HeLa cells (Lane 2), A549 cells (Lane 3) and HepG2 cells (Lane 4), using EDD antiobdy. The lane on the left is treated with systhesized peptide.
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Наименование: UBR5 Antibody.