| Объем | 100 мкл |
| Синонимы | Suppressor of T-cell receptor signaling 2, STS-2, Cbl-interacting protein 4, CLIP4, T-cell ubiquitin ligand |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P57075 |
| Иммуноген | Synthesized peptide derived from internal of human UBASH3A. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.<br/><br/>Wattenhofer M., Hum. Genet. 108:140-147(2001).<br/>Feshchenko E.A., Oncogene 23:4690-4706(2004).<br/>Hattori M., Nature 405:311-319(2000).<br/> <br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Cell biology |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from LOVO cells, HuvEc cells and K562 cells, using UBASH3A antibody.
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Наименование: UBASH3A Antibody.