SP100 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | DKFZp686E07254, FLJ00340, FLJ34579, Lysp100b, nuclear antigen Sp100 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P23497 | | Иммуноген | Synthesized peptide derived from Internal of human SP100. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to . Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to . Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.<br/><br/>Dent A.L., Blood 88:1423-1426(1996).<br/>Seeler J.-S., Proc. Natl. Acad. Sci. U.S.A. 95:7316-7321(1998).<br/>Szostecki C., J. Immunol. 145:4338-4347(1990).<br/> <br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Tags & Cell Markers,Immunology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HT29 cells, using SP100 antibody.
 | | | |
Информация для заказа |
Наименование: SP100 Antibody.