| Объем | 50 мкл |
| Синонимы | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-), TDP1 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9NUW8 |
| Иммуноген | Recombinant Human Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA) |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IHC, IP, Recommended dilution: WB:1:200-1:2000, IHC:1:20-1:200, IP:1:200-1:2000 |
| Примечание | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antigen Affinity Purified |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot
All lanes: Tyrosyl-DNA phosphodiesterase 1 antibody at 8µg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: Mouse lung tissue
Lane 3: Rat brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 69, 42 kDa
Observed band size: 69 kDa
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Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA023352ESR1HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA023352ESR1HU at dilution of 1:100
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Наименование: TDP1 Antibody.