RRP8 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | KIAA0409, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O43159 | | Иммуноген | Synthesized peptide derived from internal of human HUCE1. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.<br/><br/>Yazaki M., Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.<br/>Ishikawa K., DNA Res. 4:307-313(1997).<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from MCF-7 cells, using HUCE1 antibody.
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Наименование: RRP8 Antibody.