PTK2B (Ab-402) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FADK 2, FAK2, Focal adhesion kinase 2, PTK2B, Proline-rich tyrosine kinase 2 RAFTK | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q14289 | | Иммуноген | Peptide sequence around aa.400~404 (D-I-Y-A-E) derived from Human Pyk2. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 | | Примечание | Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.<br/><br/>Gluck SL, et al. (2004) J Clin Invest, 114(12): 1696-1699<br/>Benzing T, et al. (2001) Proc Natl Acad Sci U S A, 98(17): 9784-9789<br/>Tian D, et al. (2002) Mol Cell Biol, 22(8): 2650-2662<br/>Lu Z, et al. (2001) Mol Cell Biol, 21(12): 4016-4031<br/>Krishnan HH, et al. (2006) J Virol, 80(3): 1167-1180<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Cancer,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 cells using Pyk2(Ab-402) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Pyk2(Ab-402) Antibody(left) or the same antibody preincubated with blocking peptide(right).
 | Immunofluorescence staining of methanol-fixed Hela cells using Pyk2(Ab-402) Antibody.
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Наименование: PTK2B (Ab-402) Antibody.