PTK2 (Ab-576/577) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FADK 1, FAK1, PTK2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q05397 | | Иммуноген | Peptide sequence around aa.574~578/575~579 (T-Y-Y-K-A) derived from Human FAK. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 | | Примечание | Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.<br/><br/>Parsons, J.T. et al. (2000) Oncogene 19, 5606-5613.<br/>Schaller, M.D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688.<br/>Chen, H.C. et al. (1996) J. Biol. Chem. 271, 26329-26334.<br/>Calalb, M.B. et al. (1995) Mol. Cell. Biol. 15, 954-963.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Cancer,Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HT29 and Hela cells using FAK(Ab-576/577) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using FAK(Ab-576/577) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: PTK2 (Ab-576/577) Antibody.