PTGS2 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | COX2, GRIPGHS, PGHS2, CYCLOOXYGENASE 2, GLUCOCORTICOID-REGULATED INFLAMMATORY PROSTAGLANDIN G/H SYNTHASE | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P35354 | | Иммуноген | Synthesized peptide derived from human Cox2. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 | | Примечание | Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.<br/><br/>Nathalie Bonnefoy, Mol. Cell. Biol., Apr 2001, 21: 2359 - 2372.<br/>Keith P. Choe, J. Exp. Biol., May 2006, 209: 1696 - 1708<br/>D. Shelley Lupold, PNAS, Sep 1999, 96: 11670.<br/>Axel J. Baumgarten, AACR Meeting Abstracts, Mar 2004, 2004: 1078.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cancer,Cardiovascular,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Cox2 antibody.
 | Immunofluorescence analysis of A549 cells, using Cox2 antibody.
 | Western blot analysis of extracts from A549 cells, using Cox2 antibody.
 | Western blot analysis of extracts from HeLa cells (Lane 2), and A549 cells (Lane 3), using Cox2 antiobdy. The lane on the left is treated with systhesized peptide.
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Наименование: PTGS2 Antibody.