PLCG1 (Ab-771) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Phospholipase C gamma 1, PLC148, PHOSPHOLIPASE C-148, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P19174 | | Иммуноген | Synthesized non-phosphopeptide derived from human PLCG1 around the phosphorylation site of tyrosine 771 (P-D-Y-G-A). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.<br/><br/>Denis Tvorogov, J. Cell Sci., Feb 2005, 118: 601 - 610.<br/>Brenda J. Irvin, Mol. Cell. Biol., Dec 2000, 20: 9149 - 9161.<br/>Benoit Poulin, J. Biol. Chem., Feb 2000, 275: 6411.<br/>Ichiro Nakamura, J. Cell Biol., Jan 2001, 152: 361. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cancer,Cardiovascular,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PLCG1 (Ab-771) antibody.
 | Western blot analysis of extracts from COS7 cells treated with EGF (200ng/ml, 30min), using PLCG1 (Ab-771) antibody.
 | Western blot analysis of extracts from COS7 cells (Lane 2), and JK cells (Lane 3), using PLCG1 (Ab-771) antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: PLCG1 (Ab-771) Antibody.