| Объем | 100 мкл |
| Синонимы | TSFP1, Sp1 transcription factor, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P08047 |
| Иммуноген | Peptide sequence around phosphorylation site of threonine 739 (T-A-T(p)-P-S) derived from human SP1 |
| Источник | Rabbit |
| Видовая специфичность | Human, Rat |
| Применение | ELISA, WB,WB:1:500-1:1000 |
| Примечание | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-a G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.<br/><br/>Thiesen HJ,et al.(1990)Nucleic Acids Res.18(11):3203-9.<br/>Zutter MM,et al.(1997) Blood.90(2):678-89.<br/>Lou Z,et al.(2005)Cancer Res.65(3):1007-17<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Thr739 |
| Области исследований | Epigenetics and Nuclear Signaling,Metabolism,Stem cells |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 3T3 cells treated with starvation using SP1(Phospho-Thr739) Antibody.
 |
| | |
Наименование: Phospho-SP1 (Thr739) Antibody.