Phospho-RPS6KA1 (Thr573) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | KS6A1, p90RSK1, RSK1, RPS6KA1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q15418 | | Иммуноген | Peptide sequence around phosphorylation site of threonine 573(L-M-T(p)-P-C) derived from Human p90 RSK. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:100 | | Примечание | <p>Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.<br/><br/>Eiichi Takahashi, J. Biol. Chem., Jul 1999, 274: 20206. <br />Ye Zhang, J. Biol. Chem., May 2002, 277: 19042 - 19048. <br />Ganesh R. Panta, Mol. Cell. Biol., Mar 2004, 24: 1823 - 1835. <br /></p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Thr573 | | Области исследований | Epigenetics and Nuclear Signaling,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 cells treated with UV using p90 RSK (Phospho-Thr573) Antibody.The lane on the right is treated with the antigen-specific peptide.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p90 RSK (Phospho-Thr573) antibody (left)or the same antibody preincubated with blocking peptide (right).
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA240123 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-RPS6KA1 (Thr573) Antibody.
Примечание: дополнительная информация (на английском языке). |
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