Phospho-PTK2 (Tyr576/Tyr577) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FADK 1, FAK1, PTK2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q05397 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 576/tyrosine 577 (S-T-Y(p)-Y(p)-K-A) derived from Human FAK. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IF,WB:1:500-1:1000, IF:1:100-1:200 | | Примечание | <p>Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. <br /><br />Parsons, J.T. et al. (2000) Oncogene 19, 5606-5613 <br />Schaller, M.D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688. <br />Cobb, B.S. et al. (1994) Mol. Cell. Biol. 14, 147-155. <br />Chen, H.C. et al. (1996) J. Biol. Chem. 271, 26329-26334.</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr576/Tyr577 | | Области исследований | Cancer,Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HT29 cells untreated or treated with PMA using FAK(phospho-Tyr576/Tyr577) Antibody.
 | Immunofluorescence staining of methanol-fixed Hela cells using FAK(phospho-Tyr576/Tyr577) Antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA217230 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-PTK2 (Tyr576/Tyr577) Antibody.
Примечание: дополнительная информация (на английском языке). |
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