| Объем | 100 мкл |
| Синонимы | PAK5, PAK 6, kinase PAK6, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9P286/Q9NQU5 |
| Иммуноген | Peptide sequence around phosphorylation site of Serine 602/560(R-K-S(p)-L-V) derived from Human PAK5/6. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB,WB:1:500-1:1000 |
| Примечание | <p>This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. <br/><br/>Yang F., J. Biol. Chem. 276:15345-15353(2001).<br />Wagner T., Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.<br />Sjoeblom T., Science 314:268-274(2006).<br /></p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Ser602/Ser560 |
| Области исследований | Neuroscience,Cell biology,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from HeLa cells (Lane 2), using PAK5/6 (Phospho-Ser602/Ser560) Antibody. The lane on the left is treated with antigen-specific peptide.
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Наименование: Phospho-PAK7/PAK6 (Ser602/Ser560) Antibody.