| Объем | 100 мкл |
| Синонимы | CCAAT/enhancer-binding protein alpha C/EBP alpha CEBPA, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P49715 |
| Иммуноген | Peptide sequence around phosphorylation site of threonine 230 (P-P-T(p)-P-V) derived from Human C/EBP-alpha. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB,WB:1:500-1:1000 |
| Примечание | <p>The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.<br/><br/>Xanthopoulos K.G. Biochem. Biophys. Res. Commun. 215:106-113(1995)<br />Schalwijk J. Biol. Chem. Hoppe-Seyler 378:373-379(1997)<br />SeattleSNPs variation discovery resource Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases<br /></p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Thr230 |
| Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cardiovascular,Metabolism,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from cos-7 cells (Lane 2), using C/EBP-? (Phospho-Thr230) Antibody. The lane on the left is treated with antigen-specific peptide.
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Наименование: Phospho-CEBPA (Thr230) Antibody.