Phospho-YAP1 (Ser127) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | YAP65, YAP1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P46937 | | Иммуноген | Peptide sequence around phosphorylation site of serine127(A-H-S(p)-S-P) derived from Human YAP . | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact.<br/><br/>Sorrentino G, et al. (2014) Nat Cell Biol 16, 357-66 <br />Yang S, et al. (2014) Cell Signal 26, 343-51 <br />Sun W, et al. (2014) Mol Biol Rep 41, 947-56</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser127 | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from COS7 tissue using YAP (Phospho-Ser127) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA593016 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-YAP1 (Ser127) Antibody.
Примечание: дополнительная информация (на английском языке). |
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