Phospho-PRKCB (Ser661) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | PIM-1, EC 2.7.11.1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P05771 | | Иммуноген | Peptide sequence around phosphorylation site of serine 661 (G-F-S(p)-Y-T) derived from Human PKCB. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1.<br /><br />Zhu M, Chen J, Jiang H, Miao C (2013) Cardiovasc Diabetol 12, 13 <br />Leonard TA, et al. (2011) Cell 144, 55-66 <br />Qiao M, et al. (2010) Mol Cell 38, 512-23</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser661 | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HeLa cells treated with Heatshock using Phospho-PKCB (Ser661) antibody.The lane on the right is treated with the antigen-specific peptide.
 | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA067031 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-PRKCB (Ser661) Antibody.
Примечание: дополнительная информация (на английском языке). |
|
