Phospho-PDGFRB (Tyr740) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CD140b, PDGF-R-beta, PDGFR, PGFRB, kinase PDGFR-beta | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P09619 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 740 (G-G-Y(p)-M-D) derived from Human PDGFR beta. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>PDGF Receptor beta encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.<br/><br/>Mitchell D, et al. (2007) J Biol Chem 282, 15606-18Wu JH, et al. (2006) J Biol Chem 281, 37758-72 . Bae YS, et al. (2000)J Biol Chem 275, 10527-31.</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr740 | | Области исследований | Cancer,Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HepG2 cells treated with EGF using Phospho-PDGFR beta (Tyr740) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA979025 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-PDGFRB (Tyr740) Antibody.
Примечание: дополнительная информация (на английском языке). |
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