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/ Каталог / Реагенты для научных исследований / Антитела / Поликлональные антитела Cusabio

Phospho-NFKB1 (Ser907) Antibody

Спецификация

Объем100 мкл
Синонимыp50, KBF1, NF-kB1, NFKB-p50, NFkappaB
КлональностьPolyclonal Antibody
ОрганизмHuman
uniprotP19838
ИммуногенPeptide sequence around phosphorylation site of serine 907(P-L-S(p)-P-A) derived from Human NFκB-p105.
ИсточникRabbit
Видовая специфичностьHuman
ПрименениеELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:100
Примечание<p> NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling, active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.</p><p> </p><p>Beg A.A., Baldwin A.S. Jr.Oncogene 9:1487-1492(1994)</p><p>Guizani-Tabbane L., Ben-Aissa K., Belghith M., Sassi A., Dellagi K.Infect. Immun. 72:2582-2589(2004)</p><p>Beinke S., Robinson M.J., Hugunin M., Ley S.C.Mol. Cell. Biol. 24:9658-9667(2004)</p><p> </p>
Клональность1Polyclonal
ИзотипIgG
КоньюгатNon-conjugated
БуфферSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Формаliquid
ХранениеUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очисткиAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
АбревеатураPhospho-Ser907
Области исследованийEpigenetics and Nuclear Signaling,Cancer,Cell biology,Immunology,Signal transduction
Ссылка на страницу на сайте производителяссылка
Western blot analysis of extract from HeLa cells untreated or treated with TNF-α using NF-kappa;B p105(phospho-Ser907) antibody.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NF-κB p105(phospho-Ser907) antibody.
  

Информация для заказа

Область использования:Производство:Cusabio
Метод:Антитела 
Объем:100 мкл 
Кат. номер:CSB-PA925652
Цена (с НДС 20%):по запросуВ корзину
Phospho-NFKB1 (Ser907) AntibodyНаименование: Phospho-NFKB1 (Ser907) Antibody.
Примечание: дополнительная информация (на английском языке).
   
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