| Объем | 50 мкл |
| Синонимы | Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX |
| Тип антител | Recombinant Antibody |
| Species | Human |
| UniProt ID | P16104 |
| Иммуноген | A synthesized peptide |
| Видовая специфичность | Human |
| Применение | ELISA, WB, Recommended dilution: WB:1:3000-1:10000 |
| Клональность | Monoclonal |
| Изотип | Rabbit IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Affinity-chromatography |
| Области исследований | Epigenetics and Nuclear Signaling |
| Аббревиатура | Histone H2AX |
| Примечание | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. |
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Western Blot
Positive WB detected in:293 whole cell lysate
All lanes:Phospho-Histone H2AX (S139) antibody at 0.23µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 15 KDa
Observed band size: 15 KDa
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Наименование: Phospho-Histone H2AX (S139) Antibody.