| Объем | 100 мкл |
| Синонимы | ILK1, p59ILK, kinase ILK, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q13418 |
| Иммуноген | Peptide sequence around phosphorylation site of Serine 246(I-F-S(p)-H-P) derived from Human ILK. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, IHC,IHC:1:50-1:100 |
| Примечание | <p>Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.<br/><br/>Hannigan G.E., Nature 379:91-96(1996).<br />Janji B., Oncogene 19:3069-3077(2000).<br />Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.</p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Ser246 |
| Области исследований | Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemical analysis of paraffin-embedded human brain tissue using ILK (Phospho-Ser246) antibody (left)or the same antibody preincubated with blocking peptide (right).
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Наименование: Phospho-ILK (Ser246) Antibody.