| Объем | 100 мкл |
| Синонимы | Activating transcription factor 4, activating transcription factor 4 (tax-responsive enhancer element B67), ATF4, cAMP response element-binding protein 2, cAMP-dependent transcription factor ATF-4 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P18848 |
| Иммуноген | Synthesized peptide derived from C-terminal of human ATF4. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production By similarity. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4.<br/><br/>Tsujimoto A., J. Virol. 65:1420-1426(1991).<br/>Karpinski B.A., Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992).<br/>Dunham I., Nature 402:489-495(1999).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from A549 cells and Jurkat cells, using ATF-4 (Ab-219) antibody.
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Наименование: ATF4 (Ab-219) Antibody.