Phospho-BTK (Tyr223) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | AGMX1, ATK, kinase Btk, BPK, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q06187 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 223 (A-L-Y(p)-D-Y) derived from Human BTK. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. <br/><br/>Sulekha Verma, J. Biol. Chem., Feb 2001, 276: 4671 - 4676.<br />Yan M. Li, Cancer Res., Nov 2003, 63: 7630 - 7633.<br />Malti Nikrad, Mol. Cancer Ther., Mar 2005, 4: 443 - 449.<br />Feng Dong, Infect. Immun., Mar 2005, 73: 1861 - 1864.<br />Hiroo Ueno, Mol. Biol. Cell, Feb 2</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr223 | | Области исследований | Immunology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Hela cells treated with serum using BTK (phospho-Tyr223) Antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA142166 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-BTK (Tyr223) Antibody.
Примечание: дополнительная информация (на английском языке). |
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