| Объем | 100 мкл |
| Синонимы | AIRE1, APECED, APS1, APSI, PGA1 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | O43918 |
| Иммуноген | Peptide sequence around phosphorylation site of Serine156 P-G-S(p)-Q-L) derived from Human AIRE. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:1000 |
| Примечание | <p>The function of the protein encoded by this gene is not well defined, however it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE-1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE-2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE-3 includes the same exon 1-8-9 sequences as found in AIRE-2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized. <br/><br/>Nagamine K., Nat. Genet. 17:393-398(1997).<br />Aaltonen J., Nat. Genet. 17:399-403(1997).<br />Hattori M., Nature 405:311-319(2000).<br /></p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Ser156 |
| Области исследований | Epigenetics and Nuclear Signaling,Immunology |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from HeLa cells treated with Hu using AIRE (Phospho-Ser156) Antibody.The lane on the right is treated with the antigen-specific peptide.
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Наименование: Phospho-AIRE (Ser156) Antibody.